2CBFly-NBOMe

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N-(2-Methoxybenzyl)-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran-4-yl)-2-aminoethane

2CBFly-NBOMe (NBOMe-2C-B-FLY, Cimbi-31) is a compound indirectly derived from the phenethylamine hallucinogen 2C-B, and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like NBOMe-2C-I. It was discovered in 2002,[1] and further researched by Ralf Heim at the Free University of Berlin,[2] and subsequently investigated in more detail by a team at Purdue University led by David Nichols.[3] It acts as a potent partial agonist for the 5HT2A serotonin receptor subtype,[4][5] with a Ki of 0.14nM at the rat 5HT2A receptor.

References

  1. Template:Cite journal
  2. Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  3. Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.
  4. Template:Cite journal
  5. Template:Cite doi

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