AET

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The Basics

Introduction and Basic Description

Alpha-Ethyltryptamine, or AET, is a tryptamine empathogen/entactogen with mild psychedelic properties. It was developed in the 1960s as a prescription antidepressant, but when it was shown to cause agranulocytosis (lowered white blood cell count that leaves the immune system severely weakened) it was removed from the market, This was the result of people taking it every day as an antidepressant and there is no evidence that its occasional use recreationally could result in agranulocytosis. AET use as a recreational designer drug in the 1980s resulted in it being placed in schedule 1, the most tightly controlled category of substances in the United States. It is very closely related to AMT but has quite different effects, in that it is less stimulating and less visual of an experience. AET seems to be more of a pure empathogen/entactogen like MDMA than AMT. It differs from MDMA in that it is not very stimulating, and the mental and physical effects are clearly those of a tryptamine.

Timeline of Experience

According to Erowid the onset of AET is 30-90 minutes. The whole experience lasts for 4-6 hours.

Effects

AET is a tryptamine empathogen/entactogen, that is often compared to MDMA or to its close relative AMT. It has quite different effects from either however. It is less stimulating than either MDMA or AMT, and its visual effects are limited to blurred vision and sometimes simple closed-eye visuals. Due to its lack of stimulation it does not interfere with sleep, as described in TiHKAL in several experience reports. AET is primarily a releaser of serotonin, while also releasing norepinephrine and dopamine, and also acts as a serotonin receptor agonist. Essentially the effects are similar to MDMA, but with a tryptamine aspect to the body high and headspace.

Dosages

According to Erowid 75mg is a threshold dose, while 100-160mg is a fully active dose. In TiHKAL Shulgin confirms these doses, stating that 50mg was not active, but reports enjoyable experiences with doses ranging from 100mg to 160mg. These numbers apply to oral dosing only.

Method of administration

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Method 1

Method 2

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Problems

Contraindications and Overdose

AET should never be combined with MAOIs since it is a serotonin releaser. This combination could result in serotonin syndrome.

Negative Short-Term Side Effects

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Negative Long-Term Side Effects

AET has been shown to be neurotoxic. Also, it was removed from the market as an antidepressant because it increased the risk of agranulocytosis, a very dangerous condition that weakens the immune system by deceasing white blood cell counts. For these reasons AET should only be used occasionally.

Addiction and Withdrawal Issues

Harm Reduction

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Legal Issues

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Background and Chemistry

History of Drug

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Chemistry

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Pharmacology & Mechanism of Action

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Trip reports and links

Trip Reports

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Links