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The Basics

Introduction and Basic Description

Methoxetamine is a dissociative anesthetic drug that was developed and marketed in the late 2000s. It is similar in terms of structure and effect to ketamine and PCP.

Timeline of Experience

Half life is roughly 3 hours, double that of ketamine's. For rapidly absorbed routes like buccal, injected, rectal, snorted etc:

  • Onset in 10-20 mins
  • 1-3h main effects
  • 3-6h after effects

The duration is strongly dose dependent. Large doses will leave one feeling very strange for up to 24 hours. Many users note an "afterglow" the next day.


Varied, depending on dosage. At low doses, stimulation, mood lift, increased enjoyment of music, muscular relaxation. At higher doses ataxia, dissociation, numbness, double vision, euphoria, loss of inhibitions, out of body experiences, hallucinations, time distortion. Drunken, dreamlike feeling, notably less "stoning" and immobilising than ketamine.


The threshold dose for MXE, for most people, is around 10 or 15 mg. Typical doses are around 30 to 50 mg, with anything larger than this likely to yield a strong experience. Tolerance builds over time, and heavy users can consume upwards of 100 mg in a single dose. Dosage is dependent on ROA, with most users agreeing that injection requires the lowest doses, followed by, in decreasing order of efficacy, rectal, sublingual, oral and intranasal administration.

Method of administration

Snorted, injected (IM/IV), eaten (oral), sublingual, rectal, smoked (as freebase). Unusually, many users report that intranasal administration (snorting) is less effective than oral dosing.


"Mexi", "Minx", "Jipper"


Contraindications and Overdose

Contraindicated with other stimulants due to a tendency for mania and reckless behaviour. Alcohol, GHB, Ketamine, and other CNS depressants are likely potentiators. Some have reported bad experiences combining MXE and ketamine or alcohol.

Negative Short-Term Side Effects

Memory loss, ridiculous behaviour, panic/anxiety attacks, confusion, nausea, vomiting, tinnitus, headaches, depersonalization.

Negative Long-Term Side Effects

Dissociative toxidrome. Loss of social interaction. Possible loss of frontal lobe mass or bladder integrity. Stimulant psychosis.

Addiction and Withdrawal Issues

Psychological addiction is definitely possible, compare ketamine addiction.

Harm Reduction

Legal Issues

Possible analogue of ketamine. It is uncontrolled in the US and Canada. Subject to a temporary class order in the UK, so illegal to import or sell but legal to possess and use.

Background and Chemistry

History of Drug



NMDA receptor antagonist, serotonin re uptake inhibitor (SRI)[1] and a putative dopamine reuptake inhibitor. Purportedly a ligand for the mu opiate receptor, though this is disputed.


Trip Reports & Links

Trip Reports


(1) Roth, B.L., Gibbons, S., Arunotayanun, W., Huang, X., Setola, V., Treble, R., Iverson, L (2013). "The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor." Plus One. Retrieved 4 April 2013.

Additional Resources/External Links


Methoxetamine Wiki Document Credits
Formatted by Vaya with appreciated additional contributions by Solipsis