Pharmacology Discovery and Structure–Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists

[Psychestim]

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00082

 

[Skorpio]

Sweet, a new scaffold! I wonder how the subjective effects are, as (to my knowledge) it is unclear if more selective agonists of 5HT2A produce subjectively less "rich" experiences.

 

[Rectify]

Adding an N,alpha-methyl would, in almost all likelihood, improve LPH-5's activity.

N,alpha-methyl-LPH-5
(S)-3-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-methyl-piperidine