In my experience, it is. I've tried it twice now, a few bumps of DMXE before 2-CB and we continued to bump DMXE throughout and then added 4-HO-MET. Me and my 2 other friends had a great time. We just hung around the house and listened to music and talked and played video games.
I also tried DMXE + 4-HO-MET for a solo trip and enjoyed it.
DMXE gets me in a mindset where I feel like my minds already leaning enough in that direction and that I feel like I'm ready to receive the message. Makes the transition into the trip a lot more smooth than going from without the dissociative, although I'm sure that can be dose dependent