StagnantReaction
Bluelighter
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- Mar 19, 2004
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Several prospective studies have used stored blood collected up to 14 years before the onset of cancer have shown associations between IGF-1 and prostate cancer, premenopausal breast cancer, and colon cancer.
"Given the increasing evidence of the risk of cancer, caution should be exercised in the exogenous use of either insulin-like growth factor-I or substances that increase concentrations of it."
British Medical Journal October 7, 2000
Thus, it is highly likely that IGF-1 promotes the transformation of human breast cells to cancerous forms. IGF-1 is also a growth factor for already cancerous breast and colon cancer cells, promoting their progression and invasiveness. Other studies connect IGF-1 to Type 1 Diabetes, especially in infants.
While IGF-1 may only be absorbed in limited quantities in healthy subjects, this is likely not be the case for those suffering from various conditions that can cause increased intestinal permeability, such as celiac disease, Crohn's disease, autism, cirrhosis, and cow's milk allergy, just to name a few.
In addition, the use of various medications, such as aspirin and other NSAIDs can increase intestinal permeability and it is estimated that 10% to 20% of the general "healthy" population suffers from this condition as well.
It was also demonstrated that people who consumed 3 servings of milk daily had a 10% higher serum IGF-1 level and almost a 10% lower level IGF Binding Protein 4 (IGBP-4) than those drinking less than 1-1/2 servings. It has been proven that those with less IGF Protein 4 are more at risk of IGF-1 related carcinogenic risk factors.
It is not enough to look at healthy adults and say that the intestinal absorption of IGF-1 is negligible. Rather, the most vulnerable in society need to be protected. Infants are unstudied and probably most susceptible in this case..
With these risk factors in mind, it's very probable that the cause of the dropping median age for puberty in women can be linked to rBGH intake, due to the link involving early puberty in girls being associated with a higher risk for breast cancer. However, exposure to higher than natural levels of steroid hormones through hormone-treated meat or poultry has never been documented. Large epidemiological studies have not been done to see whether or not early puberty in developing girls is associated with having eaten growth hormone-treated foods.
We do not have hard evidence to pin on IGF-1, except for the risks it increases. But it is extremely possible that these hormones are playing a large role in carcinogen and growth risks.
"Given the increasing evidence of the risk of cancer, caution should be exercised in the exogenous use of either insulin-like growth factor-I or substances that increase concentrations of it."
British Medical Journal October 7, 2000
Thus, it is highly likely that IGF-1 promotes the transformation of human breast cells to cancerous forms. IGF-1 is also a growth factor for already cancerous breast and colon cancer cells, promoting their progression and invasiveness. Other studies connect IGF-1 to Type 1 Diabetes, especially in infants.
While IGF-1 may only be absorbed in limited quantities in healthy subjects, this is likely not be the case for those suffering from various conditions that can cause increased intestinal permeability, such as celiac disease, Crohn's disease, autism, cirrhosis, and cow's milk allergy, just to name a few.
In addition, the use of various medications, such as aspirin and other NSAIDs can increase intestinal permeability and it is estimated that 10% to 20% of the general "healthy" population suffers from this condition as well.
It was also demonstrated that people who consumed 3 servings of milk daily had a 10% higher serum IGF-1 level and almost a 10% lower level IGF Binding Protein 4 (IGBP-4) than those drinking less than 1-1/2 servings. It has been proven that those with less IGF Protein 4 are more at risk of IGF-1 related carcinogenic risk factors.
It is not enough to look at healthy adults and say that the intestinal absorption of IGF-1 is negligible. Rather, the most vulnerable in society need to be protected. Infants are unstudied and probably most susceptible in this case..
With these risk factors in mind, it's very probable that the cause of the dropping median age for puberty in women can be linked to rBGH intake, due to the link involving early puberty in girls being associated with a higher risk for breast cancer. However, exposure to higher than natural levels of steroid hormones through hormone-treated meat or poultry has never been documented. Large epidemiological studies have not been done to see whether or not early puberty in developing girls is associated with having eaten growth hormone-treated foods.
We do not have hard evidence to pin on IGF-1, except for the risks it increases. But it is extremely possible that these hormones are playing a large role in carcinogen and growth risks.