2C-I

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2,5-Dimethoxy-4-iodophenethylamine


The Basics

Introduction and Basic Description

2C-I is a psychedelic phenethylamine invented by Alexander Shulgin that became a very popular research chemical. It is similar to other drugs in the 2c-x family. It causes open and closed eye visuals, strong stimulation, and psychedelic thought distortion, though it is less "deep" than other psychedelics according to many people.

Timeline of Experience

2C-I takes 45 minutes to 1.5 hours to take effect depending on stomach contents. The trip lasts for 6-8 hours. Residual stimulation may last for several hours after the trip.

Effects

2C-I is a hallucinogen and entactogen very similar to 2C-B. It causes both closed and open eye visuals, though they are not as pronounced as with 2C-E. It has an almost amphetamine-like physical stimulation, and a classic phenethylamine body high. It is widely considered to be less "deep" or mentally intense than most psychedelics, and for this reason many experienced psychedelic users recommend it as a beginner trip.

Dosages

15-25mg orally is a common dose of 2C-I. Insufflated doses are much lower, around 5mg.

Method of administration

Oral

Oral dosing is the most common way of taking 2C-I. Its main downside is the length of time it takes to kick in, but it also has the least pronounced side effects compared to other ROAs.

Snorted/Insufflated

Snorting 2C-I is notoriously painful. It takes effect within minutes, and kicks in very strongly. Unfortunately this can result in a heavy body load, vomiting, and extreme burning pain in the nose. sinuses, and back of the throat.

IV/IM

Rectal

Problems

Contraindications and Overdose

SSRIs will make the 2C-I experience less intense, as they do to most psychedelics. No LD50 has been found for 2C-I, but anything above 30mg is a very heavy dose, and too much could easily result in hospitalization.

Negative Short-Term Side Effects

2C-I can cause tooth grinding, muscle tension, anxiety, nausea (mostly on the come up), and inability to sleep.

Negative Long-Term Side Effects

Reports on internet forums (including Bluelight) have indicated that 2C-I is more prone to causing HPPD than other psychedelics, but this is purely anecdotal evidence.

Addiction and Withdrawal Issues

Harm Reduction

Due to its high potency a milligram scale is necessary for safely dosing this compound.

Legal Issues

2C-I is unscheduled in the United States, but is illegal under the analogue act because of its similarity to 2C-B, a schedule I drug.

Background and Chemistry

History of Drug

Alexander Shulgin invented 2C-I and tested the compound on himself and his associates. Shulgin published the synthesis and a description of the effects in his book PiHKAL. The drug became an extremely popular and widely available research chemical by the early 2000s.

Chemistry

Please help develop this section by providing information about the physical structure of the compound.

Pharmacology

Explain what the drug does in the body/brain.

Mechanism of Action

More ADD stuff, talk about neurotransmitters and GABA and SERT receptors and stuff.

Trip reports and links

Trip Reports

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Links