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The Basics

Introduction and Basic Description

AMT (alpha-Methyltryptamine) is a psychedelic/stimulant/entactogen first developed in the 1960s as an anti-depressant at Upjohn, a pharmaceutical firm based in Michigan. It was sold in 5mg and 10mg pills in the Soviet Union for medical purposes but gradually gained fame as a research chemical in the 1990s for its recreational potential.

Timeline of Experience

An oral dose of AMT takes between 30 and 120 minutes to come up with an onset of 30 to 120 minutes before hand although some users have reported to have an onset as long as 180 minutes. During this time users have been known to experience nausea ranging from a mild stomach ache to violent puking whereas others have a complete lack of nausea.

Due to the long time taken for the effects to develop, users have been known to redose thinking that nothing is happening. Please don't be tempted to do this as this could lead to bad experiences or potentially fatal overdoses.

AMT's peak lasts between 4 and 7 hours with reported stimulation, euphoric moood lift, CEVs (Closed Eye Visuals) and mild OEVs (Open Eye Visuals) usually taking the forms of patterns. Users have reported euphoric rushes similar to MDMA, albeit milder. Lower doses tend to be mainly stimulated, whereas the higher doses become more psychedelic.

The come down can last between 2 and 8 hours, usually with no after effects the next day although some people have said they have experienced a mood lift for a few days after their use.


The positive effects of AMT include stimulation, mood lift, visual patterning, CEVs, increase in awareness, heightened appreciation of music, and empathy.

AMT also comes with negative side effects such as anxiety/tension, nausea/headaches, decreased motor skills, aching muscles, jaw clenching, and confusion. [1]


An oral dose of AMT has been reported to be active in doses as low as 5mg which some users have used as a mood lifter throughout a day. Common doses for someone new to AMT would be 20-35mg which tends to have a more stimulating effect. From 40mg+ the psychedelic side becomes more apparent with 60mg+ tending to be a heavy dose.

When smoked a much smaller dosage should be used. Common doses are between 5mg and 10mg, any higher is seen as a strong dosage.

Method of administration

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Smoked (Freebase)


  • Amtrak
  • Amthrax [4]
  • Trymene [5]

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Contraindications and Overdose

Caution should be exercised by individuals using AMT, as AMT possesses monoamine oxidase inhibition (MAOI) properties. In his book TIHKAL: The Continuation, Alexander Shulgin expands upon AMT's role as an MAOI:

"In the 1960's there was quite a bit of interest at a couple of pharmaceutical houses in the indole analogues of amphetamine. Both the alpha-methylated tryptamine (AMT) and the alpha-ethylated homologue (AET) were found to be effective monoamine oxidase inhibitors, and both were clinically studied as potential antidepressants. The ethyl compound became a commercial drug, offered by the Upjohn Company as Monase, but now is considered to be without medical use and is a Schedule I drug. It is interesting that this methyl compound, AMT was also a medically available antidepressant in the Soviet Union in the 1960's and was sold under the name of Indopan, in 5 and 10 milligram tablets." [2]

Negative Short-Term Side Effects

Sleep can sometimes be difficult on AMT, especially due to nausea and the time of the overall experience (usually longer than 12 hours). Other side effects include anxiety, jaw tension, and tachycardia.

Negative Long-Term Side Effects

As AMT is a serotonin releasing agent there may be a risk of serotonergic neurotoicity at high doses. [3]

Addiction and Withdrawal Issues

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Harm Reduction

As AMT is active in doses as low as 5mg when taken orally and as low as 1mg when smoked.) Care should be taken when measuring doses. An analytical (milligram) scale should be used to enure accuracy. [6]

As AMT has MAOI properties, dietary restrictions should be observed to ensure foods or beverages containing tryptamine are not ingested. [7]

Legal Issues

AMT is currently scheduled in multiple countries which may result in prosecution if caught with it. Below is the status in several countries: [8]

  • Australia: Schedule 8
  • Germany: Teil B
  • Greece: Controlled
  • Japan: Controlled
  • Russia: Controlled
  • Sweden: Controlled
  • UK: Not Controlled
  • US: Schedule I

Background and Chemistry

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History of Drug

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  • IUPAC Name: 2-(1H-indol-3-yl)-1-methyl-ethylamine
  • Tryptamine structure with a hydrogen being substituted for a methyl group on the alpha carbon. This relationship to tryptamine is identical to the relationship between amphetamine and phenetyhlamine which also has a methyl substituent at the alpha carbon.
  • AMT has a similar structure to serotonin, the differences being a hydroxyl group on the 5 position and no methyl group on the alpha carbon.


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Mechanism of Action

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Trip reports & Links

Trip Reports



(1) Erowid (2013). "AMT Effects." AMT Information. Retrieved 14 January 2013.

(2) Shulgin, Alexander (1997). "AMT." Tihkal: The Continuation. Transform Press, page 567.

(3) Wikipedia (2013). "Alpha-Methyltryptamine: Dosage and Effects." Retrieved 14 January 2013.

(4) Erowid (2013). "AMT FAQ." AMT Information. Retrieved 17 January 2013.

(5) Wikipedia (2013). "Alpha-Methyltryptamine Legality." Retrieved 17 January 2013.

(6) Erowid (2013). "AMT." AMT Dose. Retrieved 17 January 2013.

(7) (2013). "What Foods You Should Avoid on MAOIs." MAOI Dietary Restrictions. Retrieved 17 January 2013.

(8) Erowid (2013). "AMT." AMT Law Vault: Legal Status. Retrieved 17 January 2013.


Alpha-Methyltryptamine Wiki Document Credits
Gratitude goes to Jackeh for compiling and submitting this Wiki content. Minor contributions and formatting by vaya.