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The molecular structure of STS-135.

STS-135 or 5F-2NE1 (N-adamantyl-1-fluoropentylindole-3-carboxamide) is a designer drug that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors. It has been found as an ingredient in synthetic cannabis smoking blends. Although its name would suggest that it is American in origin, STS-135 appears to have originated in Thailand. No information has yet been published on its receptor binding or pharmacological profile, but it is structurally related to compounds such as AM-1248, 2NE1, AKB48, and AB-001, which are known to be potent cannabinoid agonists.

See also


  • Jankovics P, Váradi A, Tölgyesi L, Lohner S, Németh-Palotás J, Balla J (August 2011). "Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary". Forensic Science International. doi:10.1016/j.forsciint.2011.07.011. PMID 21813254.
  • Research on Head Shop drugs in Dublin: Part 2
  • US patent 7820144, Makriyannis A, Deng H, "Receptor selective cannabimimetic aminoalkylindoles", granted 2010-10-26
  • Frost, J. M.; Dart, M. J.; Tietje, K. R.; Garrison, T. R.; Grayson, G. K.; Daza, A. V.; El-Kouhen, O. F.; Yao, B. B. et al. (2010). "Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity". Journal of Medicinal Chemistry 53 (1): 295. doi:10.1021/jm901214q. PMID 19921781.